Pyruvate Kinase PKM

Preferred Label : Pyruvate Kinase PKM;

NCIt synonyms : CTHBP; THBP1; Cytosolic Thyroid Hormone-Binding Protein; Pyruvate Kinase Muscle Isozyme; Pyruvate Kinase 2/3; Epididymis Secretory Protein Li 30; PKM; Thyroid Hormone-Binding Protein 1; p58; Pyruvate Kinase Isozymes M1/M2; Opa-Interacting Protein 3; Pyruvate Kinase Isozymes M1-M2; OIP-3; EC 2.7.1.40; Pyruvate Kinase PKM Isoform M2; PKM2;

NCIt definition : Pyruvate kinase PKM (531 aa, 58 kDa) is encoded by the human PKM gene. This protein is involved in muscle cell glycolysis and may play a role in bacterial pathogenesis.;

NCIt note : Pyruvate kinase PKM translocates to the nucleus in response to different apoptotic stimuli. This is sufficient to induce cell death that is isoform specific and independent from either caspase or pyruvate kinase PKM enzymatic activity. (UniProt); UniProt considers isoform M2 the canonical form of the pyruvate kinase PKM protein.;

Details

Origin ID

C74443;

UMLS CUI

C2698922;

OMIM relation
- Pyruvate kinase, muscle [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PKM Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Pyruvate Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycolysis/Gluconeogenesis Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Pyruvate Metabolism Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Glycolysis [NCIt concept]
- Phosphorylation Process [NCIt concept]
is_target
- Cancer Cell Metabolism Modulator OMT-111 [NCIt concept]
- Fluorine F 18 DASA-23 [NCIt concept]
- Pyruvate Kinase M2 Isoform Activator TP-1454 [NCIt concept]

Keyword's position in hierarchy(ies) :

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