Preferred Label : Cancer Cell Metabolism Modulator OMT-111;
NCIt definition : A cancer cell metabolism modulator, with potential antineoplastic activity. Upon administration,
OMT-111 inhibits pyruvate dehydrogenase kinase (PDH), resulting in the activation
of the citric acid cycle in mitochondria, which leads to the degradation of hypoxia-inducible
factor 1-alpha (HIF1A). This may result in decreased expression of HIF1A downstream
target genes important to tumor growth and survival, a reduction in tumor cell proliferation,
and the induction of tumor cell apoptosis. OMT-111 may stimulate apoptosis in cancer
cells by restoring normal mitochondrial-induced apoptotic signaling.;
Molecule name : OMT 111; OMT-111;
NCI Metathesaurus CUI : CL1647867;
Origin ID : C178399;
UMLS CUI : C5555007;
Semantic type(s)
- concept_is_in_subset
- has_target
