Preferred Label : Fluorine F 18 DASA-23;
NCIt synonyms : 18F-DASA-23; F18-labeled PKM2 Inhibitor DASA-23; 1-((2-Fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine; F18-labeled Pyruvate Kinase M2 Inhibitor DASA-23; [18F]DASA23; [18F]DASA-23;
NCIt definition : A radiotracer composed of DASA-23, a pyruvate kinase isoform M2 (PKM2) ligand, conjugated
to the radioisotope fluorine F 18, with potential use for imaging of PKM2-expressing
tumor cells upon positron emission tomography (PET). Upon administration of fluorine
F 18 DASA-23, the DASA-23 moiety selectively targets and is taken up by tumor cells
that express PKM2. Upon binding to PKM2 and following PET, PKM2-expressing tumor cells
can be visualized and the metabolic activity of the tumor cells can be assessed through
the quantitation of PKM2 expression levels. PKM2, an enzyme that plays a key role
in the glycolytic reprogramming, metabolic activity and rapid proliferation of tumor
cells, is selectively overexpressed in various tumor cell types. Tumor uptake of fluorine
F 18 DASA-23 is positively correlated with PKM2 expression.;
NCI Metathesaurus CUI : CL552138;
Origin ID : C150418;
UMLS CUI : C4725715;
Semantic type(s)
- concept_is_in_subset
- has_target
