GCK wt Allele - CISMeF

Preferred Label : GCK wt Allele;

NCIt synonyms : HHF3; HKIV; HXKP; LGLK; Glucokinase (Hexokinase 4) Gene; Hexokinase D, Pancreatic Isozyme Gene; GLK; PNDM1; FGQTL3; Liver Glucokinase Gene; HK4; Maturity Onset Diabetes of the Young 2 Gene; MODY2; Glucokinase wt Allele; GK; Hexokinase 4 Gene;

NCIt definition : Human GCK wild-type allele is located in the vicinity of 7p13 and is approximately 55 kb in length. This allele, which encodes hexokinase-4 protein, is involved in the synthesis of hexose-6-phosphates, which are utilized in glycogen synthesis and glycolysis. Mutations in the gene are associated with permanent neonatal diabetes mellitus 1, maturity-onset diabetes of the young 2, familial hyperinsulinemic hypoglycemia 3 and late-onset noninsulin-dependent diabetes mellitus.;

GenBank Accession Number : AF041014;

Details

Origin ID

C201644;

OMIM relation
- Glucokinase [OMIM gene]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7p13 [NCIt concept]
gene_is_element_in_pathway
- Amino and Nucleotide Sugars Metabolism Pathway [NCIt concept]
- Butirosin and Neomycin Biosynthesis Pathway [NCIt concept]
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- Galactose Metabolism Pathway [NCIt concept]
- Glycolysis/Gluconeogenesis Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Maturity Onset Diabetes of the Young Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_plays_role_in_process
- Glycogenesis Induction [NCIt concept]
- Glycolysis [NCIt concept]
- Phosphorylation Process [NCIt concept]

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