Alpha-Aminoadipic Semialdehyde Dehydrogenase

Preferred Label : Alpha-Aminoadipic Semialdehyde Dehydrogenase;

NCIt synonyms : Alpha-AASA Dehydrogenase; P6c Dehydrogenase; Aldehyde Dehydrogenase 7 Family Member A1; EC 1.2.1.31; ALDH7A1; Antiquitin-1; EC 1.2.1.3; Delta1-Piperideine-6-Carboxylate Dehydrogenase; Betaine Aldehyde Dehydrogenase; EC 1.2.1.8; Aldehyde Dehydrogenase Family 7 Member A1; Antiquitin 1;

NCIt definition : Alpha-aminoadipic semialdehyde dehydrogenase (539 aa, 58 kDa) is encoded by the human ALDH7A1 gene. This protein plays a role in betaine synthesis and the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.;

NCIt note : Alpha-aminoadipic semialdehyde dehydrogenase is expressed as at least 3 isoforms. Isoform 1 (hALDH7A1_v1) is expressed in the mitochondrion and isoform 2 (hALDH7A1_v2) is expressed in the cytosol; the transcripts for these two isoforms arise due to use of alternative translation initiation sites. (EntrezGene);

Détails

Origin ID

C214471;

OMIM relation
- Aldehyde dehydrogenase 7 family, member a1 [OMIM gene]
gene_encodes_gene_product
- ALDH7A1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arginine and Proline Metabolism Pathway [NCIt concept]
- Ascorbate and Aldarate Metabolism Pathway [NCIt concept]
- Beta-Alanine Metabolism Pathway [NCIt concept]
- Fatty Acid Metabolism Pathway [NCIt concept]
- Glycerolipid Metabolism Pathway [NCIt concept]
- Glycine, Serine and Threonine Metabolism Pathway [NCIt concept]
- Glycolysis/Gluconeogenesis Pathway [NCIt concept]
- Histidine Metabolism Pathway [NCIt concept]
- Lysine Degradation Pathway [NCIt concept]
- One Carbon Pool by Folate Pathway [NCIt concept]
- Pyruvate Metabolism Pathway [NCIt concept]
- Tryptophan Metabolism Pathway [NCIt concept]
- Valine, Leucine and Isoleucine Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Amino Acid Metabolic Process [NCIt concept]
- Catabolic Process [NCIt concept]
- Detoxification [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

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