Preferred Label : IDH1 Inhibitor TQB3454;
NCIt synonyms : IDH1 Mutant Inhibitor TQB3454;
NCIt definition : An orally bioavailable, small molecule inhibitor of isocitrate dehydrogenase type
1 (IDH1; IDH-1; IDH1 [NADP ] soluble) mutant forms, with potential antineoplastic
activity. Upon oral administration, IDH1 inhibitor TQB3454 specifically binds to and
inhibits certain mutant forms of IDH1, thereby inhibiting the formation of the oncometabolite
2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated
signaling and leads to both an induction of cellular differentiation and an inhibition
of cellular proliferation in tumor cells expressing IDH1 mutations. IDH1 mutations
are highly expressed in certain malignancies; they initiate and drive cancer growth
by both blocking cell differentiation and catalyzing the formation of 2HG.;
Molecule name : TQB 3454; TQB-3454;
NCI Metathesaurus CUI : CL1920593;
Origin ID : C201300;
UMLS CUI : C5854650;
Semantic type(s)
- concept_is_in_subset
- has_target
