Ivosidenib - CISMeF

Preferred Label : Ivosidenib;

NCIt definition : An orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. IDH1, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG.;

UNII : Q2PCN8MAM6;

InChIKey : WIJZXSAJMHAVGX-DHLKQENFSA-N;

CAS number : 1448347-49-6;

Drug name : Tibsovo;

Molecule name : AG-120; AG 120;

NCI Metathesaurus CUI : CL471818;

Codes from synonyms : 287;

Details

Origin ID

C114383;

UMLS CUI

C4682397;

CISMeF manual mappings
- ivosidenib [MeSH concept]
Currated CISMeF NLP mapping
- Ivosidenib [ICD-11 Extension code]
- Ivosidenib [SMS substance]
- Ivosidenib (substance) [SNOMED CT concept]
- ivosidenib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing ivosidenib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ivosidenib (substance) [SNOMED CT concept]
- Product containing ivosidenib (medicinal product) [SNOMED CT concept]
- ivosidenib [MeSH Supplementary Concept]
- ivosidenib [ATC Code]
Validated automatic mappings to BTNT
- ivosidenib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Isocitrate Dehydrogenase [NADP] Cytoplasmic [NCIt concept]
is_component_of_chemotherapy_regimen
- Azacitidine/Ivosidenib Regimen [NCIt concept]
- Ivosidenib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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