ERBB2 wt Allele

Preferred Label : ERBB2 wt Allele;

NCIt synonyms : V-ERB-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Gene; HER2; NGL; c-ERBB-2; NEU Gene; Human EGF Receptor 2 Gene; TKR1; HER2/neu; ERBB2; Erb-b2 Receptor Tyrosine Kinase 2 wt Allele;

NCIt definition : Human ERBB2 wild-type allele is located in the vicinity of 17q21.1 and is approximately 29 kb in length. This allele, which encodes receptor tyrosine-protein kinase erbB-2 protein, plays a role in EGF receptor signal transduction pathways and cellular growth. Amplification or overexpression of this gene is involved in the progression of several forms of cancer, including breast and ovarian tumors.;

GenBank Accession Number : NM_004448;

Détails

Origin ID

C52166;

UMLS CUI

C1704824;

Currated CISMeF NLP mapping
- HER2(776-788) [MeSH concept]
- HER2(776-788) [MeSH Supplementary Concept]
OMIM relation
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Glioblastoma [NCIt concept]
- Lung Adenocarcinoma [NCIt concept]
- Ovarian Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 17: 35109922-35138436 [NCIt concept]
gene_in_chromosomal_location
- 17q21.1 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Breast Ductal Carcinoma [NCIt concept]
- Pancreatic Ductal Adenocarcinoma [NCIt concept]
gene_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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