Pancreatic Ductal Adenocarcinoma

Preferred Label : Pancreatic Ductal Adenocarcinoma;

NCIt synonyms : Pancreatic Tubular Adenocarcinoma; Ductal Adenocarcinoma of the Pancreas; Pancreas Ductal Adenocarcinoma; Ductal Adenocarcinoma of Pancreas; PDA; PDAC;

NCIt definition : An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor.;

Neoplastic status : Malignant;

Details

Origin ID

C9120;

UMLS CUI

C1335302;

Automatic exact mappings (from CISMeF team)
- Posterior interventricular branch of right coronary artery [FMA entity]
- posterior descending artery [Radlex concept]
Currated CISMeF NLP mapping
- Adenocarcinoma of pancreatic duct (disorder) [SNOMED CT concept]
- Ductal adenocarcinoma of pancreas [MedDRA Preferred Term]
- Ductal adenocarcinoma of pancreas [ICD-11 More detail]
- Pancreas ductal adenocarcinoma [PASCAL descriptor]
- ductal pancreatic adenocarcinoma [Disease (Nov.)]
- pancreatic ductal adenocarcinoma [DO Concept]
DO Cross reference
- pancreatic ductal adenocarcinoma [DO Concept]
Disease excludes abnormal cell
- Malignant Neuroendocrine Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
- Secretory Adenocarcinoma Cell [NCIt concept]
Disease may have findings
- Abdominal Pain [NCIt concept]
- Jaundice [NCIt concept]
- Pruritus [NCIt concept]
- Weight Loss [NCIt concept]
False automatic mappings
- Microphthalmia, syndromic 9 [OMIM Phenotype]
- Patent arterial duct [ICD-11 Subcategory]
- Patent ductus arteriosus [HPO term]
- Patent ductus arteriosus 1 [OMIM Phenotype]
- ductus arteriosus, patent [MeSH Descriptor]
- personal digital assistant [MeSH concept]
Has associated anatomic sites
- Digestive System [NCIt concept]
- Pancreas [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Adenocarcinoma of pancreatic duct (disorder) [SNOMED CT concept]
- Ductal adenocarcinoma of pancreas [MedDRA Preferred Term]
- Pancreas ductal adenocarcinoma [PASCAL descriptor]
- ductal pancreatic adenocarcinoma [Disease (Nov.)]
- pancreatic ductal adenocarcinoma [DO Concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Acinar Cell Differentiation [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Low Grade Neuroendocrine Lesion [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Fibrotic Stroma Formation [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Glandular Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Glandular Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Digestive System [NCIt concept]
- Exocrine Pancreas [NCIt concept]
- Pancreatic Duct [NCIt concept]
- Pancreatobiliary System [NCIt concept]
disease_mapped_to_gene
- BRCA2 Gene [NCIt concept]
- CDKN2A Gene [NCIt concept]
- ERBB2 Gene [NCIt concept]
- KRAS Gene [NCIt concept]
- SMAD4 Gene [NCIt concept]
- TP53 Gene [NCIt concept]
disease_may_have_associated_disease
- Diabetes Mellitus [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 12 [NCIt concept]
- Gain of Chromosome 7 [NCIt concept]
- Loss of Chromosome 12 [NCIt concept]
- Loss of Chromosome 13 [NCIt concept]
- Loss of Chromosome 17 [NCIt concept]
- Loss of Chromosome 18 [NCIt concept]
- Loss of Chromosome 1p [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 6 [NCIt concept]
- Loss of Chromosome 8p [NCIt concept]
- Loss of Chromosome 9p [NCIt concept]
disease_may_have_molecular_abnormality
- AKT2 Gene Amplification [NCIt concept]
- BRCA2 Gene Mutation [NCIt concept]
- CDKN2A Gene Inactivation [NCIt concept]
- ERBB2 Gene Amplification [NCIt concept]
- KRAS Gene Mutation [NCIt concept]
- MAP2K4 Gene Inactivation [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]
- SMAD4 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]
may_be_associated_disease_of_disease
- Hereditary Atypical Mole Melanoma Syndrome [NCIt concept]
pathogenesis_of_disease_involves_gene
- CDKN2A Gene [NCIt concept]
- CDKN2A wt Allele [NCIt concept]
- ERBB2 Gene [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- KRAS Gene [NCIt concept]
- KRAS wt Allele [NCIt concept]
- SMAD4 Gene [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- TP53 Gene [NCIt concept]
- TP53 wt Allele [NCIt concept]
- TP53*1 Allele [NCIt concept]

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