" /> Alpha-Fetoprotein - CISMeF





Preferred Label : Alpha-Fetoprotein;

NCIt synonyms : Alpha-1-Fetoprotein; Alpha-Fetoglobulin; Alpha Fetoprotein; Alpha Fetal Protein;

NCIt related terms : AFP;

NCIt definition : Alpha-fetoprotein (609 aa, 69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation.;

Alternative definition : NCI-GLOSS: A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor.;

NCIt note : Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink);

Codes from synonyms : CDR0000044861; CDR0000046208; 05864;

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11/05/2024


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