TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes

Preferred Label : TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes;

NCIt synonyms : Autologous Genetically Modified AFPC332 T-cells; AFP-C332 T Cells; Anti-AFP TCR-expressing Autologous CTLs; Autologous Genetically Modified AFPC332 T Cells; AFP-C332 CTLs;

NCIt definition : A preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for human alpha-fetoprotein (AFP), with potential antineoplastic activity. Following administration, the TCR-specific, alpha fetoprotein-enhanced autologous T-lymphocytes recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers.;

Molecule name : AFPC332;

NCI Metathesaurus CUI : CL524771;

Details

Origin ID

C136982;

UMLS CUI

C4527154;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Alpha-Fetoprotein [NCIt concept]

Keyword's position in hierarchy(ies) :

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