NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral
vector to express a T-cell receptor mimetic (TCRm) construct targeting the immunogenetic
human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) complexed with human
leukocyte antigen (HLA)-A*02 (HLA-A*02/AFP), with potential immunomodulatory and antineoplastic
activities. Upon administration, autologous anti-HLA-A*02/AFP TCRm-expressing T-cells
ET140203 specifically recognize and selectively bind to AFP peptides presented by
HLA-A*02. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of AFP-expressing
tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed
in adult tissues, is overexpressed in certain tumors of endodermal origin and plays
a key role in tumor cell proliferation and survival. AFP is processed into peptides
and presented by class I major histocompatibility complexes (MHCs) on the surface
of tumor cells.;