NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral
vector to express a T-cell receptor mimetic (TCRm) construct targeting as of yet undisclosed
tumor associated antigen(s) (TAA), with potential immunomodulatory and antineoplastic
activities. Upon administration, the autologous TCRm-expressing T-cells ET140203 specifically
recognize and selectively bind to the as of yet undisclosed TAA(s). This results in
cytotoxic T-lymphocyte (CTL)-mediated killing of tumor cells expressing the TAA(s).;