" /> Alpha-fetoprotein - CISMeF





Preferred Label : Alpha-fetoprotein;

Symbol : AFP;

CISMeF acronym : AFP;

Type : Gene;

Description : Alpha-fetoprotein is a major plasma protein in the fetus, where it is produced by the yolk sac and liver (Ingram et al., 1981). In the adult its concentration is very low except when a tumor such as hepatoma or teratoma is present. The similarity in physical properties of AFP and albumin (ALB; 103600) and the fact that their presence is inversely related suggested that AFP is the fetal counterpart of serum albumin. The alpha-fetoprotein and albumin genes are syntenic; this may represent an ontogenically significant arrangement with switch from AFP to albumin, comparable to the hemoglobin F to hemoglobin A switch (see 141800). Mammalian AFP and serum albumin genes are thought to have arisen through duplication of an ancestral gene 300 to 500 million years ago. The AFP gene is a member of a multigenic family that comprises the related genes encoding ALB, alpha-albumin, or afamin (AFM; 104145), and vitamin D-binding protein, otherwise known as group-specific component (GC; 139200) (Gabant et al., 2002).;

Ensembl ID : ENSG00000081051;

Prefixed ID : *104150;

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25/05/2025


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