CDKN3 wt Allele

Preferred Label : CDKN3 wt Allele;

NCIt synonyms : KAP1 Gene; Cyclin-Dependent Kinase Interactor 1 Gene; Cyclin-Dependent Kinase Inhibitor 3 (CDK2-Associated Dual Specificity Phosphatase) wt Allele; Cyclin-Dependent Kinase Interacting Protein 2 Gene; CIP2 Gene; Kinase-Associated Phosphatase Gene; CDK2-Associated Dual Specificity Phosphatase Gene; CDI1 Gene; Cyclin-Dependent Kinase Inhibitor 3 Gene; KAP Gene;

NCIt definition : Human CDKN3 wild-type allele is located within 14q22 and is approximately 23 kb in length. This allele, which encodes cyclin-dependent kinase inhibitor 3 protein, may play a role in cell cycle regulation. Defects in CDKN3 allele have been identified in patients with hepatocellular carcinoma (HCC) and the allele is deleted, mutated, or overexpressed in several kinds of cancers.;

GenBank Accession Number : NM_005192;

Details

Origin ID

C49514;

UMLS CUI

C1707119;

OMIM relation
- Cyclin-dependent kinase inhibitor 3 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Hepatocellular Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 14: 53933476-53956682 [NCIt concept]
gene_in_chromosomal_location
- 14q22 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Beckwith-Wiedemann Syndrome [NCIt concept]
gene_is_element_in_pathway
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Protein Dephosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients