NCIt definition : A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Contusugene
ladenovec induces tumor cells that have been transfected with the vector to produce
wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant
number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts
an antitumor effect by blocking cell cycle progression at the G1/S regulation point,
activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis
when DNA damage is irreparable. (NCI04);
UNII : YPN57899MY;
CAS number : 600735-73-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 600735-73-7
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