" /> Contusugene Ladenovec - CISMeF





Preferred Label : Contusugene Ladenovec;

NCIt synonyms : Adenovirus p53; Adeno-p53; p53 Gene, Ad5CMV; Ad5CMV p53 Gene; Ad-p53; Ad5CMV-p53 Gene;

NCIt definition : A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Contusugene ladenovec induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04);

UNII : YPN57899MY;

CAS number : 600735-73-7;

Drug name : Advexin;

Molecule name : RPR/INGN-201; INGN-201; INGN 201;

NSC code : 683550;

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Keyword's position in hierarchy(ies) : arborescence

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30/05/2025


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