Negative Regulation of G1 to S Transition

Preferred Label : Negative Regulation of G1 to S Transition;

NCIt synonyms : G1-S Arrest; G1/S Arrest;

NCIt definition : G1-S Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular commitment at the G1 restriction point to DNA replication and the proliferative cycle. G1 to S is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.;

Details

Origin ID

C21230;

UMLS CUI

C1517339;

Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Mitogen [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_has_result_biological_process
- S Phase Process [NCIt concept]
biological_process_involves_gene_product
- Bromodomain-Containing Protein 7 [NCIt concept]
- Protein Lin-9 Homolog [NCIt concept]
biological_process_is_part_of_process
- Cell Cycle Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- G1 to S Transition Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- 7-Hydroxystaurosporine [NCIt concept]
- Benzoylphenylurea [NCIt concept]
- Contusugene Ladenovec [NCIt concept]
- Hydroxyurea [NCIt concept]
process_involves_gene
- BRD7 Gene [NCIt concept]
- BRD7 wt Allele [NCIt concept]
- LIN9 Gene [NCIt concept]
- LIN9 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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