Benzoylphenylurea

Preferred Label : Benzoylphenylurea;

NCIt synonyms : BPU; Benzamide, N-(aminocarbonyl)-N-phenyl-;

NCIt related terms : N-(AMINOCARBONYL)-N-PHENYLBENZAMIDE;

NCIt definition : A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of antitubulin agent.;

UNII : M10I9SO6RR;

CAS number : 1195179-46-4;

NSC code : 639829;

Codes from synonyms : CDR0000045004; CDR0000044374;

Details

Origin ID

C2618;

UMLS CUI

C0935907;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- DNA Polymerase [NCIt concept]
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of G1 to S Transition [NCIt concept]
- Negative Regulation of Microtubule Polymerization [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA Polymerase [NCIt concept]
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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