" /> Hydroxyurea - CISMeF





Preferred Label : Hydroxyurea;

NCIt synonyms : Hydroxycarbamide;

NCIt related terms : Litalir; SQ 1089; Onco-carbide; Hydrea;

NCIt definition : A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;

UNII : X6Q56QN5QC;

InChIKey : VSNHCAURESNICA-UHFFFAOYSA-N;

CAS number : 127-07-1;

Drug name : Hydrea; Droxia; Syrea; Onco-Carbide; Litalir; Oxeron;

Molecule name : WR 83799; SQ-1089;

Chemical formula : CH4N2O2;

NSC code : 32065;

ChEBI ID : CHEBI:44423;

Codes from synonyms : CDR0000045308; NSC0032065; 00782; 259;

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04/05/2025


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