Ribonucleotide Reductase

Preferred Label : Ribonucleotide Reductase;

NCIt synonyms : EC 1.17.4.-;

NCIt definition : Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. It consists of two subunits, M1 Chain and M2 Chain. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. (NCI);

Details

Origin ID

C17101;

UMLS CUI

C0035547;

Automatic exact mappings (from CISMeF team)
- ADP reductase [MeSH Supplementary Concept]
- CDP reductase [MeSH Supplementary Concept]
- ICP10 protein, herpes simplex virus type 2 [MeSH Supplementary Concept]
- NrdB protein, E coli [MeSH Supplementary Concept]
- NrdD protein, alcaligenes [MeSH Supplementary Concept]
- NrdE protein, E coli [MeSH Supplementary Concept]
- NrdF protein, E coli [MeSH Supplementary Concept]
- NrdF protein, bacteria [MeSH Supplementary Concept]
- NrdG protein, E coli [MeSH Supplementary Concept]
- NrdG protein, alcaligenes [MeSH Supplementary Concept]
- NrdJa protein, pseudomonas aeruginosa [MeSH Supplementary Concept]
- NrdJb protein, pseudomonas aeruginosa [MeSH Supplementary Concept]
- RNR2 protein, S cerevisiae [MeSH Supplementary Concept]
- RRM2B protein, human [MeSH Supplementary Concept]
- RRR1 protein, xenopus [MeSH Supplementary Concept]
- Rnr1 protein, S cerevisiae [MeSH Supplementary Concept]
- Rrm1 protein, mouse [MeSH Supplementary Concept]
- Rrm2b protein, mouse [MeSH Supplementary Concept]
- TSO2 protein, arabidopsis [MeSH Supplementary Concept]
- anaerobic ribonucleotide reductase [MeSH Supplementary Concept]
- m45 protein, mouse cytomegalovirus 1 [MeSH Supplementary Concept]
- nrdG protein, bacteria [MeSH Supplementary Concept]
- nrdG protein, enterobacteria phage T4 [MeSH Supplementary Concept]
- p53R2 protein, zebrafish [MeSH Supplementary Concept]
- ribonucleotide reductase 2A, arabidopsis [MeSH Supplementary Concept]
- ribonucleotide reductase 2B, arabidopsis [MeSH Supplementary Concept]
- ribonucleotide reductase M2 [MeSH Supplementary Concept]
- ribonucleotide reductase R2 subunit [MeSH Supplementary Concept]
- ribonucleotide reductases [MeSH Descriptor]
- ribonucleotide reductases [MeSH concept]
Biochemical function of gene products
- Ribonucleotide Reductase Subunit [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ribonucleotide reductases [MeSH concept]
- ribonucleotide reductases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Aerosol Gemcitabine [NCIt concept]
- Fermented Wheat Germ Extract [NCIt concept]
- Fludarabine Phosphate [NCIt concept]
- Fosgemcitabine Palabenamide [NCIt concept]
- Gemcitabine [NCIt concept]
- Gemcitabine Elaidate [NCIt concept]
- Gemcitabine Hydrochloride [NCIt concept]
- Gemcitabine Hydrochloride Emulsion [NCIt concept]
- Gemcitabine Liposome FF-10832 [NCIt concept]
- Gemcitabine Prodrug LY2334737 [NCIt concept]
- Gemcitabine-Releasing Intravesical System [NCIt concept]
- Hydroxyurea [NCIt concept]
- Oral Fludarabine Phosphate [NCIt concept]
- RNR Inhibitor COH29 [NCIt concept]
- RNR Subunits Interaction Inhibitor TAS1553 [NCIt concept]
- Roducitabine [NCIt concept]
- Triapine [NCIt concept]
gene_product_has_biochemical_function
- Oxidoreductase [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Replication [NCIt concept]
has_gene_product_element
- Ribonucleoside-Diphosphate Reductase Large Subunit [NCIt concept]
- Ribonucleoside-Diphosphate Reductase M2 [NCIt concept]
- Ribonucleoside-Diphosphate Reductase Subunit M2 B [NCIt concept]
is_target
- Aerosol Gemcitabine [NCIt concept]
- Clofarabine [NCIt concept]
- Fludarabine Phosphate [NCIt concept]
- Fosgemcitabine Palabenamide [NCIt concept]
- Gemcitabine [NCIt concept]
- Gemcitabine Elaidate [NCIt concept]
- Gemcitabine Hydrochloride [NCIt concept]
- Gemcitabine Prodrug LY2334737 [NCIt concept]
- Gemcitabine-Releasing Intravesical System [NCIt concept]
- Hydroxyurea [NCIt concept]
- RNR Inhibitor COH29 [NCIt concept]
- RNR Subunits Interaction Inhibitor TAS1553 [NCIt concept]
- Triapine [NCIt concept]

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