NCIt related terms : Fludara; 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-;
NCIt definition : The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral
agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly
dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine
kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA
polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA
synthesis and inhibiting tumor cell growth.;
Alternative definition : NCI-GLOSS: A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has
not responded to treatment with other anticancer drugs or that has gotten worse. It
is also being studied in the treatment of other types of cancer. Fludara blocks cells
from making DNA and may kill cancer cells. It is a type of purine antagonist and a
type of ribonucleotide reductase inhibitor.;
UNII : 1X9VK9O1SC;
InChIKey : GIUYCYHIANZCFB-FJFJXFQQSA-N;
CAS number : 75607-67-9;
Drug name : Beneflur;
Molecule name : SH T 586;
Chemical formula : C10H13FN5O7P;
NSC code : 312887; 328002;
ChEBI ID : CHEBI:63599;
Codes from synonyms : CDR0000613209; CDR0000613208; NSC0312887;