" /> Fludarabine Phosphate - CISMeF





Preferred Label : Fludarabine Phosphate;

NCIt synonyms : Fludarabine-5'-Monophosphate; 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl); 2-F-ara-AMP; Oforta;

NCIt related terms : Fludara; 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-;

NCIt definition : The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.;

Alternative definition : NCI-GLOSS: A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. It is also being studied in the treatment of other types of cancer. Fludara blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor.;

UNII : 1X9VK9O1SC;

InChIKey : GIUYCYHIANZCFB-FJFJXFQQSA-N;

CAS number : 75607-67-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 75607-67-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Beneflur;

Molecule name : SH T 586;

Chemical formula : C10H13FN5O7P;

NSC code : 312887; 328002;

ChEBI ID : CHEBI:63599;

Codes from synonyms : CDR0000613209; CDR0000613208; NSC0312887;

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20/05/2024


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