Preferred Label : Adenovirus-Encoding E.coli PNP;
NCIt synonyms : Adenovirus Encoding Purine Nucleoside Phosphorylase; Ad/PNP;
NCIt definition : A replication-incompetent adenovirus encoding E. coli purine nucleoside phosphorylase
(Ad/PNP) used as a prodrug activating agent. Administered intratumorally, Ad/PNP expresses
the enzyme PNP, which may catalyze systematically administrated fludarabine phosphate
prodrug into its active form 2-fluoroadenine (F-Ade). F-Ade inhibits DNA polymerase
alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis
and inhibiting tumor cell growth. Localized prodrug activation provides targeted chemotherapy,
thereby potentially reducing systemic side effects.;
NCI Metathesaurus CUI : CL429005;
Origin ID : C96221;
UMLS CUI : C3272652;
Semantic type(s)
- concept_is_in_subset
- has_target
