Gemcitabine Liposome FF-10832

Preferred Label : Gemcitabine Liposome FF-10832;

NCIt synonyms : Liposomal Gemcitabine FF-10832;

NCIt definition : A liposomal formulation in which gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue, is encapsulated in liposomes, with potential antineoplastic activity. Upon administration of gemcitabine liposome FF-10832, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in premature termination of DNA replication and the induction of tumor cell apoptosis. In addition, dFdCDP inhibits ribonucleotide reductase (RNR) and reduces the deoxynucleotide pool available for DNA synthesis. This inhibits tumor cell proliferation.;

Molecule name : FF 10832; FF-10832;

NCI Metathesaurus CUI : CL1907074;

Details

Origin ID

C200252;

chemical_or_drug_affects_gene_product
- Ribonucleotide Reductase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Synthesis Inhibition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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