NCIt synonyms : 4-Amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl)pyrimidin-2(1H)-one; Fluorocyclopentenylcytosine; Cytidine Analog RX-3117;
NCIt definition : An orally available small molecule and nucleoside antimetabolite with potential antineoplastic
activity. Upon administration, tRoducitabine is taken up by cells through a carrier-mediated
transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated
to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is
incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced
by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated
into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This
eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting
enzyme in the pyrimidine-nucleotide salvage pathway.;
UNII : 0Z4A82I0JO;
InChIKey : QLLGKCJUPWYJON-HLTSFMKQSA-N;
CAS number : 865838-26-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 865838-26-2
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