" /> Roducitabine - CISMeF





Preferred Label : Roducitabine;

NCIt synonyms : 4-Amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl)pyrimidin-2(1H)-one; Fluorocyclopentenylcytosine; Cytidine Analog RX-3117;

NCIt definition : An orally available small molecule and nucleoside antimetabolite with potential antineoplastic activity. Upon administration, roducitabine is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, roducitabine also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway.;

UNII : 0Z4A82I0JO;

InChIKey : QLLGKCJUPWYJON-HLTSFMKQSA-N;

CAS number : 865838-26-2;

Molecule name : RX-3117; TV-1360;

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10/05/2025


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