DNA (Cytosine-5)-Methyltransferase 1

Preferred Label : DNA (Cytosine-5)-Methyltransferase 1;

NCIt synonyms : DNA Methyltransferase HsaI; DNA MTase HsaI; CXXC-Type Zinc Finger Protein 9; MCMT; EC 2.1.1.37; DNMT1; M.HsaI; DNA Cytosine-5-Methyltransferase 1;

NCIt definition : DNA (cytosine-5)-methyltransferase 1 protein (1613 aa, 183 kDa) is encoded by the human DNMT1 gene. This soluble, nuclear protein is involved in epigenetic modification of chromatin, catalyzing the methylation of C5 in CpG dinucleotides within DNA.;

NCI Metathesaurus CUI : CL790342;

Details

Origin ID

C73690;

UMLS CUI

C4548354;

Currated CISMeF NLP mapping
- DNA (cytosine-5-)-methyltransferase 1 [MeSH concept]
OMIM relation
- Dna methyltransferase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA (Cytosine-5-)-Methyltransferase 1 [MeSH Descriptor]
- DNA (cytosine-5-)-methyltransferase 1 [MeSH concept]
- DNMT1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNMT1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cysteine and Methionine Metabolism Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Methylation [NCIt concept]
- Methylation [NCIt concept]
is_target
- 4-Thio-2-deoxycytidine [NCIt concept]
- 5-Aza-4'-thio-2'-deoxycytidine [NCIt concept]
- DNMT1 Inhibitor NTX-301 [NCIt concept]
- Decitabine and Cedazuridine [NCIt concept]
- Roducitabine [NCIt concept]

Keyword's position in hierarchy(ies) :

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