" /> 4-Thio-2-deoxycytidine - CISMeF





Preferred Label : 4-Thio-2-deoxycytidine;

NCIt synonyms : TdCyd; T-dCyd;

NCIt related terms : 4'-THIO-2'-DEOXYCYTIDINE;

NCIt definition : An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog gets incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation.;

UNII : L76O0M313F;

CAS number : 134111-30-1;

Détails


Vous pouvez consulter :


Nous contacter.
28/07/2025


[Accueil] [Haut de page]

© CHU de Rouen. Toute utilisation partielle ou totale de ce document doit mentionner la source.