4-Thio-2-deoxycytidine

Preferred Label : 4-Thio-2-deoxycytidine;

NCIt synonyms : TdCyd; T-dCyd;

NCIt related terms : 4'-THIO-2'-DEOXYCYTIDINE;

NCIt definition : An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog gets incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation.;

UNII : L76O0M313F;

CAS number : 134111-30-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 134111-30-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Details

Origin ID

C121828;

UMLS CUI

C4050128;

Automatic exact mappings (from CISMeF team)
- 2'-deoxy-4'-thiocytidine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA (Cytosine-5)-Methyltransferase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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