DNA (Cytosine-5-)-Methyltransferase 1MeSH Descriptor
Preferred Label : DNA (Cytosine-5-)-Methyltransferase 1;
MeSH definition : A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger
motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE)
POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated
DNA, and associates with DNA replication sites in S PHASE to maintain the methylation
pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES.
It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation
independently of replication. It is responsible for maintaining methylation patterns
established in development; mutations in the DNMT1 gene are associated with HEREDITARY
SENSORY NEUROPATHY TYPE 1 class E.;
A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger
motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE)
POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated
DNA, and associates with DNA replication sites in S PHASE to maintain the methylation
pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES.
It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation
independently of replication. It is responsible for maintaining methylation patterns
established in development; mutations in the DNMT1 gene are associated with HEREDITARY
SENSORY NEUROPATHY TYPE 1 class E.