Preferred Label : 5-Aza-4'-thio-2'-deoxycytidine;
NCIt synonyms : Aza-TdC; Aza-TdCyd; 5-Aza-4-thio-2-deoxycytidine; 5-Aza-TdCyd;
NCIt definition : An orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor,
with potential DNA hypomethylating and antineoplastic activities. Upon administration,
5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds
to the active site of DNMT1, a maintenance methyltransferase that contributes to the
hypermethylation and silencing of tumor suppressor genes. The formation of covalent
DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes
CpG demethylation, and results in the re-expression and re-activation of silenced
tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated
in tumor cells, plays a key role in tumor cell proliferation.;
UNII : U2PTN0RZF6;
CAS number : 169514-76-5;
NCI Metathesaurus CUI : CL554978;
NSC code : 777586;
Origin ID : C153479;
UMLS CUI : C4727285;
Semantic type(s)
- concept_is_in_subset
- has_target
