Preferred Label : DNMT1 Inhibitor NTX-301;
NCIt definition : An orally bioavailable inhibitor of human DNA methyltransferase 1 (DNMT1), with potential
antineoplastic activity. Upon oral administration, DNMT1 inhibitor NTX-301 targets
ad binds to DNMT1, thereby inhibiting the activity of DNMT1. This may prevent DNA
methylation, induce DNA hypomethylation, and activate tumor suppressor genes silenced
by hypermethylation. This may inhibit tumor cell proliferation. DNMT1, a member of
the DNA methyltransferase (DNMT) family, plays an important role in maintaining the
DNA methylation pattern. Dysregulation of DNMT1 has been associated with a number
of cancers.;
Molecule name : NTX 301; NTX-301;
NCI Metathesaurus CUI : CL1411982;
Origin ID : C174424;
UMLS CUI : C5418096;
Semantic type(s)
- concept_is_in_subset
- has_target
