Triapine - CISMeF

Preferred Label : Triapine;

NCIt synonyms : 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone; 3-Apct; 3-AP;

NCIt related terms : OCX-0191;

NCIt definition : A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor.;

UNII : U4XIL4091C;

CAS number : 236392-56-6;

Molecule name : OCX-191; PAN-811;

NSC code : 663249;

Codes from synonyms : CDR0000044850; CDR0000044881; CDR0000367459;

Details

Origin ID

C2242;

UMLS CUI

C0210403;

Automatic exact mappings (from CISMeF team)
- 3-Aminopropyltrimethoxysilane [Substance BNPC]
- 3-aminopropane-1-sulphonic acid [Substance BNPC]
- 3-aminopropyltrimethoxysilane [MeSH Supplementary Concept]
- 3-aminopropyltrimethoxysilane [MeSH concept]
- tramiprosate [MeSH Supplementary Concept]
- tramiprosate [MeSH concept]
Currated CISMeF NLP mapping
- 3-aminopyridine-2-carboxaldehyde thiosemicarbazone [MeSH concept]
- 3-aminopyridine-2-carboxaldehyde thiosemicarbazone [MeSH Supplementary Concept]
- triapine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 3-aminopyridine-2-carboxaldehyde thiosemicarbazone [MeSH concept]
- 3-aminopyridine-2-carboxaldehyde thiosemicarbazone [MeSH Supplementary Concept]
- triapine [MeSH concept]
chemical_or_drug_affects_gene_product
- Ribonucleotide Reductase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Synthesis Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Ribonucleotide Reductase [NCIt concept]
is_component_of_chemotherapy_regimen
- 3-AP/Cisplatin/Paclitaxel [NCIt concept]
- 3-AP/Fludarabine [NCIt concept]
- Cytarabine/Triapine [NCIt concept]
- Fludarabine/Triapine [NCIt concept]
- Gemcitabine/Triapine [NCIt concept]
- Triapine/Cisplatin [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients