NCIt definition : A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity.
Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine
diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine
kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated
into DNA. This locks DNA polymerase thereby resulting in masked termination during
DNA replication. On the other hand, dFdCDP inhibits ribonucleotide reductase, thereby
decreasing the deoxynucleotide pool available for DNA synthesis. The reduction in
the intracellular concentration of dCTP potentiates the incorporation of dFdCTP into
DNA.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug that is used to treat pancreatic cancer
that is advanced or has spread. It is also used with other drugs to treat breast cancer
that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced
or has spread. It is also being studied in the treatment of other types of cancer.
Gemcitabine blocks the cell from making DNA and may kill cancer cells. It is a type
of antimetabolite.;
UNII : B76N6SBZ8R;
InChIKey : SDUQYLNIPVEERB-QPPQHZFASA-N;
CAS number : 95058-81-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 95058-81-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Chemical formula : C9H11F2N3O4;
ChEBI ID : CHEBI:175901;
Codes from synonyms : CDR0000045347; NSC0613327; 243;