Preferred Label : Gemcitabine Hydrochloride;
NCIt synonyms : dFdCyd; Difluorodeoxycytidine Hydrochloride; 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride; 2'Deoxy-2',2'-Difluorocytidine, Hydrochloride; Gemcitabine; Gemcitabine HCI;
NCIt related terms : Gemzar;
NCIt definition : The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine
with antineoplastic activity. Gemcitabine is converted intracellularly to the active
metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits
ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for
DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination
and apoptosis.;
Alternative definition : NCI-GLOSS: A drug used to treat pancreatic cancer that is advanced or has spread.
It is also used with other drugs to treat breast cancer that has spread, advanced
ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It
is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride
blocks the cell from making DNA and may kill cancer cells.;
UNII : U347PV74IL;
InChIKey : OKKDEIYWILRZIA-OSZBKLCCSA-N;
CAS number : 122111-03-9;
Drug name : Gemzar;
Molecule name : LY-188011; LY 188011;
Chemical formula : C9H11F2N3O4.HCl;
NSC code : 613327;
ChEBI ID : CHEBI:31647;
Codes from synonyms : CDR0000508952; CDR0000508951;
Origin ID : C961;
UMLS CUI : C0771488;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
