Ribonucleotide Reductase Subunit

Preferred Label : Ribonucleotide Reductase Subunit;

NCIt definition : Encoded by Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2), the M1 Chain and M2 Chain subunits compose Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI);

Details

Origin ID

C21212;

UMLS CUI

C1335783;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Ribonucleotide Reductase Subunit Gene [NCIt concept]
gene_product_has_biochemical_function
- Ribonucleotide Reductase [NCIt concept]
gene_product_is_physical_part_of
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- DNA Replication [NCIt concept]
- DNA Synthesis [NCIt concept]
is_chemical_classification_of_gene_product
- Ribonucleoside-Diphosphate Reductase Large Subunit [NCIt concept]
- Ribonucleoside-Diphosphate Reductase M2 [NCIt concept]
- Ribonucleoside-Diphosphate Reductase Subunit M2 B [NCIt concept]

Keyword's position in hierarchy(ies) :

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