Cenersen - CISMeF

Preferred Label : Cenersen;

NCIt synonyms : OL(1)p53;

NCIt definition : A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics.;

UNII : K6KJ8AZ05F;

CAS number : 415168-49-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 415168-49-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Aezea;

Molecule name : EL625;

Details

Origin ID

C37454;

UMLS CUI

C3490398;

Currated CISMeF NLP mapping
- cenersen [MeSH concept]
- cenersen [MeSH Supplementary Concept]
See also inter- (CISMeF)
- OL(1)p53 [MeSH concept]
- OL(1)p53 [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- cenersen [MeSH concept]
- cenersen [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cellular Tumor Antigen p53 [NCIt concept]
is_component_of_chemotherapy_regimen
- Cytarabine/EL625/Idarubicin [NCIt concept]

Keyword's position in hierarchy(ies) :

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