IL-2 Recombinant Fusion Protein ALT-801

Preferred Label : IL-2 Recombinant Fusion Protein ALT-801;

NCIt related terms : ALT-801;

NCIt definition : A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen with potential immunopotentiating and antineoplastic activities. The TCR moiety of IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor cells.;

UNII : QWZ40O5W6K;

CAS number : 1188450-53-4;

Molecule name : ALT-801;

Details

Origin ID

C71743;

UMLS CUI

C2346454;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ALT-801 [MeSH Supplementary Concept]
- ALT-801 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cellular Tumor Antigen p53 [NCIt concept]

Keyword's position in hierarchy(ies) :

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