IL-2 Recombinant Fusion Protein ALT-801NCIt concept
Preferred Label : IL-2 Recombinant Fusion Protein ALT-801;
NCIt related terms : ALT-801;
NCIt definition : A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized
soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen
with potential immunopotentiating and antineoplastic activities. The TCR moiety of
IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC
complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural
killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor
cells.;
UNII : QWZ40O5W6K;
CAS number : 1188450-53-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1188450-53-4
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