Preferred Label : Adenovirus-p53 Transduced Dendritic Cell Vaccine;
NCIt synonyms : Dendritic Cell-P53;
NCIt definition : A cancer vaccine consisting of autologous dendritic cells (DCs) transduced with a
recombinant adenovirus encoding p53 peptide, with potential immunomodulating activity.
Intradermal vaccination with adenoviral-p53 transduced dendritic cell vaccine may
stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response
against tumor cells expressing mutant p53, resulting in tumor cell lysis. p53, a tumor
suppressor gene, is mutated in many tumor cells, resulting in the loss of apoptosis
regulation and abnormal cell proliferation.;
NCI Metathesaurus CUI : CL416223;
Origin ID : C90542;
UMLS CUI : C2983738;
Semantic type(s)
- concept_is_in_subset
- has_target
