Preferred Label : BTG Cell Cycle Regulation Pathway;
NCIt related terms : BTG family proteins and cell cycle regulation;
Alternative definition : BIOCARTA: BTG2 is found to be one of the immediate early genes up-regulated by neural
growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional level is
also up-regulated by p53, gamma radiation, adriamycin, and UV treatment of cells.
BTG seems to be important for the cell cycle progression as BTG2 is preferentially
expressed in quiescent cells. Over-expression of BTG2 decreases the growth of NIH3T3
cells and induces neuronal differentiation and prevention apoptosis of PC12 cells.
Molecularly, BTG2 expression induces hypophosphorylation of RB and G1 arrest which
could be rescued by overexpression of cyclin D1. BTG1 and BTG2 interact with PRMT1
(predominant cellular arginine N-methyltransferase) and increase PRMT1 methyltransferase
activity. Box C domain in BTG1 and 2 are responsible for the interaction. Box C domain
alone acts as a dominant negative which blocks PRMT1 activity. PRMT1 activity is essential
for NGF induced PC12 differentiation, and blocking PRMT1 by Box C domain of BTG1 or
2 induces apoptosis. In addition, BTG2 and HoxB9 interaction enhances the transcription
of Hoxb9. Lastly, association of BTG2 and BTG1 with Caf1 is also reported to modulate
transcriptional activity of CAF1. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_btg2Pathway;
Origin ID : C39008;
UMLS CUI : C1511030;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element