Fibroblast Growth Factor 1

Preferred Label : Fibroblast Growth Factor 1;

NCIt synonyms : FGF1; aFGF; Beta-Endothelial Cell Growth Factor; FGF-1; Alpha Fibroblast Growth Factor; Prostatropin; Acidic Fibroblast Growth Factor; Endothelial Cell Growth Factor, Alpha; Endothelial Cell Growth Factor, Beta; Heparin Binding Growth Factor-1; Heparin Binding Growth Factor 1; Endothelial Cell Growth Factor; ECGF; HBGF-1; Fibroblast Growth Factor-1;

NCIt definition : Fibroblast growth factor 1 (17 aa, 155 kDa) is encoded by the human FGF1 gene. This protein plays a role in cell proliferation, angiogenesis, cell differentiation, and cell migration.;

NCIt note : Fibroblast growth factor 1 lacks a cleavable signal sequence; it is transported through the cytoplasm to the cell membrane and then secreted by a non-classical pathway that requires Cu2 ions and protein S100-A13. (UniProt);

Details

Origin ID

C20548;

UMLS CUI

C3887673;

Currated CISMeF NLP mapping
- fibroblast growth factor 1 [MeSH Descriptor]
- fibroblast growth factor 1 [MeSH concept]
False automatic mappings
- fibroblast growth factor-1 (112-147) [MeSH concept]
- fibroblast growth factor-1 (112-147) [MeSH Supplementary Concept]
OMIM relation
- Fibroblast growth factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FGF1 Gene [NCIt concept]
- Fibroblast Growth Factor Gene Family [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Heparin Binding Growth Factor [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- BTG Cell Cycle Regulation Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Organogenesis [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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