G1/S-Specific Cyclin-D1

Preferred Label : G1/S-Specific Cyclin-D1;

NCIt synonyms : BCL1; G1/S-Specific Cyclin D1; U21B31; PRAD1; Cyclin D; PRAD1 Oncogene; D11S287E; BCL-1 Oncogene; Cyclin-D1; Cyclin-D1a; G1/S-Specific Cyclin D1a; G1/S-Specific Cyclin-D1a; CCND1a; Cyclin D1a;

NCIt related terms : Cyclin D1; CCND1;

NCIt definition : G1/S-specific cyclin-D1 (295 aa, 34 kDa) is encoded by the human CCND1 gene. This protein is involved in the regulation of the G1/S transition of the cell cycle.;

NCIt note : Essential for control of the G1/S transition, cyclin D1 interacts with CDK4 and CDK6 to form a serine/threonine kinase holoenzyme and imparts substrate specificity to the complex. RB regulates cyclin D1 gene expression. Cyclin D1 expression may identify Barrett's esophagus patients at high risk for esophageal carcinoma; risk of progression to adenocarcinoma exhibits an odds ratio of 6.85. The BCL1 and PRAD1 oncogenes involve cyclin D1 gene translocations. (J Natl Cancer Inst 2000. 92:1282 & 1316, SWISS-PROT, OMIM);

Details

Origin ID

C17988;

UMLS CUI

C1741716;

Automatic exact mappings (from CISMeF team)
- BCL1 [LOINC component]
- Cyclin d1 [OMIM gene]
- cyclin D1 [HGNC gene]
- cyclin D1 [ORDO Gene]
- genes, bcl-1 [MeSH Descriptor]
- genes, bcl-1 [MeSH concept]
Currated CISMeF NLP mapping
- cyclin D1 [MeSH Descriptor]
- cyclin D1 [MeSH concept]
OMIM relation
- Cyclin d1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCND1 protein, human [MeSH concept]
- CCND1 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- CCND1 protein, human [MeSH concept]
- CCND1 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- cyclin D [MeSH Descriptor]
- cyclin D [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- CCND1 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_abnormality
- CCND1 Protein Overexpression [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- Cyclin D [NCIt concept]
gene_product_is_biomarker_type
- Prognostic Marker [NCIt concept]
gene_product_is_element_in_pathway
- BTG Cell Cycle Regulation Pathway [NCIt concept]
- Beta-Catenin Accumulation Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- WNT Signaling Pathway BioCarta [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- G1 to S Transition Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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