Cyclin Regulation of Cell Cycle Pathway

Preferred Label : Cyclin Regulation of Cell Cycle Pathway;

NCIt related terms : Cyclins and Cell Cycle Regulation;

Alternative definition : BIOCARTA: The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Key among these are p53, the cdk inhibitors (p15, p16, p18, p19, p21, p27), and Rb, all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_cellcyclePathway;

Details

Origin ID

C39025;

UMLS CUI

C1511582;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 4 Inhibitor B [NCIt concept]
- Cyclin-Dependent Kinase 4 Inhibitor C [NCIt concept]
- Cyclin-Dependent Kinase 4 Inhibitor D [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Cyclin-Dependent Kinase 7 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 2A [NCIt concept]
- G1/S-Specific Cyclin-D1 [NCIt concept]
- G1/S-Specific Cyclin-D3 [NCIt concept]
- G1/S-Specific Cyclin-E1 [NCIt concept]
- G2/Mitotic-Specific Cyclin-B1 [NCIt concept]
- M-Phase Inducer Phosphatase 1 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Retinoblastoma-Like Protein 1 [NCIt concept]
- Transcription Factor Dp-1 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Tumor Suppressor ARF [NCIt concept]
pathway_has_gene_element
- CCNB1 wt Allele [NCIt concept]
- CCND1 wt Allele [NCIt concept]
- CCND2 wt Allele [NCIt concept]
- CCND3 wt Allele [NCIt concept]
- CCNE1 wt Allele [NCIt concept]
- CDC25A wt Allele [NCIt concept]
- CDK1 wt Allele [NCIt concept]
- CDK2 wt Allele [NCIt concept]
- CDK4 wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- CDK7 wt Allele [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- CDKN1B wt Allele [NCIt concept]
- CDKN2A wt Allele [NCIt concept]
- CDKN2B wt Allele [NCIt concept]
- CDKN2C wt Allele [NCIt concept]
- CDKN2D wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RBL1 wt Allele [NCIt concept]
- TFDP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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