" /> CDKN2C wt Allele - CISMeF





Preferred Label : CDKN2C wt Allele;

NCIt synonyms : Cyclin-Dependent Kinase 4 Inhibitor C Gene; CDK6 Inhibitor p18 Gene; Cyclin-Dependent Kinase 6 Inhibitor Gene; Cyclin-Dependent Kinase Inhibitor 2C Gene; Cyclin-Dependent Kinase 6 Inhibitor p18 Gene; p18-INK4C Gene; Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) wt Allele; p18 Gene; INK4C Gene; p18-INK6 Gene; p18(INK4C) Gene; CDKN6 Gene; Cyclin-Dependent Inhibitor Gene;

NCIt definition : Human CDKN2C wild-type allele is located within 1p32 and is approximately 14 kb in length. This allele, which encodes cyclin-dependent kinase 4 inhibitor C protein, is involved in cellular growth regulation and progression from the G1 phase of the cell cycle.;

NCIt note : Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. Knockout mice studies suggested that the gene may be involved in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.;

GenBank Accession Number : NM_001262;

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12/05/2024


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