NCIt definition : Human CDKN2B wild-type allele is located within 9p21 and is approximately 27 kb in
length. This allele, which encodes cyclin-dependent kinase 4 inhibitor B protein,
plays roles in both the regulation of cell growth and tumor suppression.;
NCIt note : CDKN2B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently
mutated and deleted in a wide variety of tumors. This tumor suppressor gene is induced
by TGF beta, suggesting that p15 may act as an effector of TGFB-mediated cell cycle
arrest in growth regulation.;