CDKN2B wt Allele

Preferred Label : CDKN2B wt Allele;

NCIt synonyms : TP15; MTS2; INK4B; Cyclin-Dependent Kinase Inhibitor 2B wt Allele; P15; CDK4I; p15INK4b;

NCIt definition : Human CDKN2B wild-type allele is located within 9p21 and is approximately 27 kb in length. This allele, which encodes cyclin-dependent kinase 4 inhibitor B protein, plays roles in both the regulation of cell growth and tumor suppression.;

NCIt note : CDKN2B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This tumor suppressor gene is induced by TGF beta, suggesting that p15 may act as an effector of TGFB-mediated cell cycle arrest in growth regulation.;

GenBank Accession Number : L36844;

Détails

Origin ID

C49512;

UMLS CUI

C1705748;

Currated CISMeF NLP mapping
- p15(gag) [MeSH concept]
OMIM relation
- Cyclin-dependent kinase inhibitor 2b [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 9: 21999312-21992903 [NCIt concept]
gene_in_chromosomal_location
- 9p21 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Beckwith-Wiedemann Syndrome [NCIt concept]
gene_is_element_in_pathway
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Progression [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- G1 Phase Process [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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