G2/Mitotic-Specific Cyclin-B1

Preferred Label : G2/Mitotic-Specific Cyclin-B1;

NCIt synonyms : CCNB; CGB1; CCNB1; G2/Mitotic-Specific Cyclin B1; Cyclin B1; Cyclin B; Cyclin-B1;

NCIt definition : G2/mitotic-specific cyclin-B1 (433 aa, 48 kDa) is encoded by the human CCNB1 gene. This protein plays a role in mediating the progression of the cell cycle from G2 to mitosis.;

NCIt note : Complexed with p34(cdc2), cyclin B1 forms mitosis-promoting factor (MPF), a serine/threonine kinase holoenzyme complex. Cyclin B1 imparts substrate specificity to MPF. Phosphorylation of cyclin B1 regulates nuclear translocation of MPF during prophase, essential for the induction and coordination of M-phase events. During cell cycle progression, a change in PLK1 kinase activity appears to phosphorylate cyclin B1 and stimulate nuclear entry of cyclin B1. (SWISS-PROT, OMIM);

Details

Origin ID

C17981;

UMLS CUI

C1610382;

Currated CISMeF NLP mapping
- cyclin B1 [MeSH Descriptor]
- cyclin B1 [MeSH concept]
False automatic mappings
- cyclin B (13-59) [MeSH concept]
- cyclin B (13-59) [MeSH Supplementary Concept]
OMIM relation
- Cyclin b1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCNB1 protein, human [MeSH Supplementary Concept]
- CCNB1 protein, human [MeSH concept]
- cyclin B1 [MeSH concept]
- cyclin B1 [MeSH Descriptor]
Validated automatic mappings to NTBT
- cyclin B [MeSH concept]
- cyclin b [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCNB1 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- Cyclin B [NCIt concept]
gene_product_is_element_in_pathway
- AKAP8 in Mitosis Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- Oocyte Maturation Pathway [NCIt concept]
- Ptc1 Regulation of Cell Cycle Pathway [NCIt concept]
- SRC Tyrosine Kinase Activation Pathway [NCIt concept]
- Stathmin Pathway [NCIt concept]
gene_product_is_physical_part_of
- M-Phase Promoting Factor [NCIt concept]
gene_product_malfunction_associated_with_disease
- Laryngeal Squamous Cell Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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