Cyclin-Dependent Kinase Inhibitor 1B

Preferred Label : Cyclin-Dependent Kinase Inhibitor 1B;

NCIt synonyms : CDKN1B; p27-Kip1; p27Kip1; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor-1B; p27(KIP1);

NCIt definition : Cyclin-dependent kinase inhibitor 1B (198 aa, 22 kDa) is encoded by the human CDKN1B gene. This protein plays a role in cell cycle arrest.;

NCIt note : This protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. (LocusLink);

Details

Origin ID

C17901;

UMLS CUI

C1504812;

Currated CISMeF NLP mapping
- Cyclin-Dependent kinase inhibitor p27 [MeSH Descriptor]
- Cyclin-Dependent kinase inhibitor p27 [MeSH concept]
OMIM relation
- Cyclin-dependent kinase inhibitor 1b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CDKN1B protein, human [MeSH concept]
- CDKN1B protein, human [MeSH Supplementary Concept]
- Cyclin-Dependent kinase inhibitor p27 [MeSH Descriptor]
- Cyclin-Dependent kinase inhibitor p27 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDKN1B Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Enzyme Inhibitor Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
- Tumor Suppressor Protein [NCIt concept]
gene_product_is_biomarker_type
- Prognostic Marker [NCIt concept]
gene_product_is_element_in_pathway
- CDK Regulation Pathway [NCIt concept]
- CTCF Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- p27 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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