Cyclin-Dependent kinase inhibitor p27

Preferred Label : Cyclin-Dependent kinase inhibitor p27;

MeSH definition : A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.;

MeSH synonym : p27, cdk inhibitor; cdkn4 protein; cyclin dependent kinase inhibitor 1b; p27 cdk inhibitor; cdk inhibitor, p27; p27 kip1 protein; kip1 protein, p27; cdkn1b protein; p27kip1 protein; cdk inhibitor p27; cyclin-dependent kinase inhibitor 1b; cyclin dependent kinase inhibitor p27;

Registry Number MeSH : 147604-94-2;

Is substance : O;

Details

Origin ID

D050760;

UMLS CUI

C0169665;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]
Indexing information
- CDKN1B protein, human [MeSH Supplementary Concept]
Pharmacological action(s)
- protein kinase inhibitors [MeSH Descriptor]
Record concept(s)
- Cyclin-Dependent kinase inhibitor p27 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CDKN1B protein, human [MeSH Supplementary Concept]
- Cdkn1b protein, mouse [MeSH Supplementary Concept]
- Cdkn1b protein, rat [MeSH Supplementary Concept]
- xicl protein, xenopus [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]

Keyword's position in hierarchy(ies) :

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