p27 Regulation Pathway

Preferred Label : p27 Regulation Pathway;

NCIt related terms : Regulation of p27 Phosphorylation during Cell Cycle Progression;

Alternative definition : BIOCARTA: p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. Cancer cells in some cases have reduced levels of p27, supporting the importance of p27 in cell cycle regulation. The activity of p27 is regulated by phosphorylation, synthesis and degradation. Phosphorylation of p27 at threonine-187 by cdk2 causes p27 to associate with an SCF complex that targets p27 for proteolytic degradation. The F box protein Skp2 binds specifically to threonine-187 phosphorylated p27, recruiting it to the SCF complex for degradation. Other components of the p27 ubiquitin ligase complex include Skp1, Cul1, and Roc1/Rbx-1. Cks-1 has also been identified in a reconstituted system as an essential component for recruitment of p27 for degradation by the SCF complex. Signaling by cytokines may modulate cell survival, proliferation, or apoptosis through modulation of p27 expression. Cytokine and AKT signaling pathways activate forkhead transcription factors that induce p27 expression at the transcriptional level. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_p27Pathway;

Details

Origin ID

C39176;

UMLS CUI

C1515677;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cullin-1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]
- Cyclin-Dependent Kinases Regulatory Subunit 1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RBX1 [NCIt concept]
- G1/S-Specific Cyclin-E1 [NCIt concept]
- NEDD8 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- S-Phase Kinase-Associated Protein 2 [NCIt concept]
- Transcription Factor Dp-1 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
pathway_has_gene_element
- CCNE1 wt Allele [NCIt concept]
- CDK2 wt Allele [NCIt concept]
- CDKN1B wt Allele [NCIt concept]
- CKS1B wt Allele [NCIt concept]
- CUL1 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- NEDD8 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RBX1 wt Allele [NCIt concept]
- SKP2 wt Allele [NCIt concept]
- TFDP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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