SKP2 wt Allele

Preferred Label : SKP2 wt Allele;

NCIt synonyms : FBXL1; FBL1; FLB1; MGC1366; S-Phase Kinase-Associated Protein 2 wt Allele;

NCIt definition : Human SKP2 wild-type allele is located within 5p13 and is approximately 32 kb in length. This allele, which encodes S-phase kinase-associated protein 2, is involved in cell cycle arrest at the G1/S transition of the cell cycle. SKP2 variant alleles have been established as alleles that are causally involved in the pathogenesis of lymphomas.;

GenBank Accession Number : NM_005983;

Details

Origin ID

C49541;

UMLS CUI

C1709987;

OMIM relation
- S-phase kinase-associated protein 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 5p13 [NCIt concept]
gene_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- E2F1 Degradation Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
- p27 Regulation Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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