E2F1 Degradation Pathway

Preferred Label : E2F1 Degradation Pathway;

NCIt related terms : E2F1 Destruction Pathway;

Alternative definition : BIOCARTA: E2F-1 is a transcription factor that regulates the expression of genes involved in the cell cycle and that is involved in progression of the cell cycle from G1 into S phase. Over-expression of E2F-1 can induce cellular transformation and under-expression can repress apoptosis. Association with the tumor suppressor Rb represses E2F-1 activity, and this repression is relieved when the cdk2/cyclin E complex at the G1 to S phase transition phosphorylates Rb. Like many cell cycle regulators, E2F-1 is regulated through phosphorylation by a cyclin-dependent protein kinase, cdk2/cyclin A, and by proteolytic degradation. Phosphorylation of E2F-1 by cdk2/cyclin A leads to E2F-1 inactivation, blocking DNA binding. E2F-1 is also regulated through degradation in the proteasome at the S/G2 transition. The F box complex that degrades E2F-1 contains components shared with the complexes that target other cell cycle factors for degradation. The F box protein that specifically recruits E2F for ubiquitination and degradation is Skp2. Other components of the SCF complex include Skp1, Cul1, and cdc34. Skp2 expression is cyclical, increasing in the S/G2 transition as E2F-1 is degraded. Knowledge of E2F-1 activity and its regulation form part of the complex set of interactions regulating the cell cycle and potential targets for the treatment of cancer. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_skp2e2fPathway;

Details

Origin ID

C39232;

UMLS CUI

C1512111;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cullin-1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- G1/S-Specific Cyclin-E1 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- S-Phase Kinase-Associated Protein 2 [NCIt concept]
- Transcription Factor Dp-1 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 R1 [NCIt concept]
pathway_has_gene_element
- CCNE1 wt Allele [NCIt concept]
- CDC34 wt Allele [NCIt concept]
- CDK2 wt Allele [NCIt concept]
- CUL1 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- SKP2 wt Allele [NCIt concept]
- TFDP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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