S-Phase Kinase-Associated Protein 2

Preferred Label : S-Phase Kinase-Associated Protein 2;

NCIt synonyms : CDK2/Cyclin A-Associated Protein p45; SKP2; F-Box Protein SKP2; Cyclin A/CDK2-Associated Protein p45; p45 SKP2; F-Box/LRR-Repeat Protein 1; S-Phase Kinase-Associated Protein-2;

NCIt definition : S-phase kinase-associated protein 2 (424 aa, 48 kDa) is encoded by the human SKP2 gene. This protein is involved in the regulation of protein-protein interactions that govern the cell cycle.;

NCIt note : S-phase kinase-associated protein 2 is the substrate recognition component for the SKP1-CUL1-F-box protein E3 ubiquitin-protein ligase complex. (UniProt); S-Phase Kinase-Associated Protein 2 contains an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1.;

NCI Metathesaurus CUI : CL964446;

Details

Origin ID

C29972;

UMLS CUI

C4743184;

OMIM relation
- S-phase kinase-associated protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SKP2 protein, human [MeSH Supplementary Concept]
- Skp2 proteins [MeSH concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SKP2 Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- E2F1 Degradation Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
- p27 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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