CCNE1 wt Allele

Preferred Label : CCNE1 wt Allele;

NCIt synonyms : CGE1; Cyclin E1 wt Allele; CCNE;

NCIt definition : Human CCNE1 wild-type allele is located within 19q12 and is approximately 12 kb in length. This allele, which encodes G1/S-specific cyclin-E1 protein, is involved in the regulation of the G1/S transition of the cell cycle. Variant allelic overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.;

GenBank Accession Number : NM_001238;

Details

Origin ID

C49525;

UMLS CUI

C1707088;

OMIM relation
- Cyclin e1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_abnormality
- CCNE1 Gene Amplification [NCIt concept]
gene_has_physical_location
- 19: 34994741-35007059 [NCIt concept]
gene_in_chromosomal_location
- 19q12 [NCIt concept]
gene_is_element_in_pathway
- CDK Regulation Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cyclin E Degradation Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- E2F1 Degradation Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- p27 Regulation Pathway [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Process [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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