" /> CDK4 wt Allele - CISMeF





Preferred Label : CDK4 wt Allele;

NCIt synonyms : PSK-J3; MGC14458; CMM3; Cyclin-Dependent Kinase 4 wt Allele; Cell Division Kinase 4 Gene;

NCIt definition : Human CDK4 wild-type allele is located within 12q14 and is approximately 4 kb in length. This allele, which encodes cyclin-dependent kinase 4 protein, is involved in the regulation of cell cycle progression from G1/S phase. Variant mutated alleles are associated with tumorigenesis for a variety of cancers.;

NCIt note : CDK4 was cloned for the study of hereditary melanoma. CDC37 and HSP90 enhance CDK4 stability. Cyclin-dependent kinase inhibitor-2 (p16) inhibits CDK4. Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. In addition, multiple polyadenylation sites of this gene have been reported.;

GenBank Accession Number : U37022;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
18/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.